Featuring articles on a trial of seladelpar in primary biliary cholangitis, a trial of elafibranor in primary biliary cholangitis, cognition and memory after Covid-19, and simple versus radical hysterectomy in women with low-risk cervical cancer; a review article on cardiac rehabilitation; a case report of a woman with alternating sixth cranial nerve palsy; and a Perspective article on practicing medicine in the culture wars. We also describe a new cases series on efforts toward equity in health care.

NEJM This Week — February 29, 2024

Featuring articles on CD19 CAR T-cell therapy in autoimmune disease, tenecteplase for stroke at 4.5 to 24 hours, biomarker changes in years before Alzheimer’s disease, and a hepcidin mimetic in polycythemia vera; a review article on wearable digital health technologies for epilepsy; a case report of a man with fatigue and night sweats; and Perspective articles on direct-to-consumer platforms for antiobesity medications, on childhood obesity prevention, and on what is a mentor.

NEJM This Week — February 22, 2024

Featuring articles on frexalimab in multiple sclerosis, e-cigarettes for smoking cessation, cefepime–taniborbactam for complicated UTI, and the treatment of Wolman’s disease in an infant; review articles on treatment-resistant depression in older adults and on Behçet’s syndrome; a case report of a man with fevers; and Perspective articles on ethical issues in safety-net health systems, on secondary cancers after CAR T-cell therapy, and on being worried about white-cell counts.

NEJM This Week — February 15, 2024

Featuring articles on a phase 3 trial of resmetirom in NASH with liver fibrosis, an interleukin-23–receptor antagonist for plaque psoriasis, the neurovascular complications of F. solani meningitis, and on ocular gene therapy; a review article on coccidioidomycosis and histoplasmosis; a case report of a man with fever and headache after international travel; Medicine and Society articles on a physician attack on the FDA and on being well while doing well; and Perspective articles on the risks of normalizing parental vaccine hesitancy, on advanced HIV as a neglected disease, on the challenge of common chronic diseases, and on “the saddest waste”.

NEJM This Week — February 8, 2024

Featuring articles on an attenuated tetravalent dengue vaccine, skin antisepsis before fracture surgery, N-acetyl-l-leucine in Niemann–Pick Disease type C, in vivo CRISPR-Cas9 treatment for hereditary angioedema, and on seeing medicine more as a job than a calling; a review article on cardiac implantable electronic devices; a Clinical Problem-Solving on flipping the switch; and a Perspective article on explaining health inequities.

NEJM This Week — February 1, 2024

Featuring articles on daratumumab in myeloma therapy, the early treatment of patent ductus arteriosus with ibuprofen, measurable residual disease in chronic lymphocytic leukemia, hospital prices for physician-administered drugs, and on Asian Americans and racial justice in medicine; a review article on wearable technologies in cardiovascular medicine; a case report of an infant with inconsolable crying and weakness; and Perspective articles on minding the gap, on transforming population health, and on the heartbeat.

NEJM This Week — January 25, 2024

Featuring articles on testosterone treatment and fractures in men, long-term resynchronization–defibrillation therapy for heart failure, azithromycin to prevent infant mortality in Burkina Faso, oral simnotrelvir for adult patients with Covid-19, understanding liability risk from health care AI tools, and the rise of house staff unions; a review article on syphilis during pregnancy and congenital syphilis; a case report of a woman with melanoma and fever; and Perspective articles on responding to medical errors, on looking AHEAD to state global budgets for health care, and on broken both ways.

NEJM This Week — January 18, 2024

Featuring articles on apixaban for stroke prevention in subclinical atrial fibrillation, repotrectinib for ROS1 fusion–positive lung cancer, acoramidis in transthyretin amyloid cardiomyopathy, low-dose calcium supplementation in pregnancy, and the financialization of health in the United States; a review article on peripartum cardiomyopathy; a case report of a woman with bleeding after a snakebite; and Perspective articles on the overdose crisis among U.S. adolescents, on accuracy and equity in clinical risk prediction, on centering women of color in academic medicine, and on the buddy system.

NEJM This Week — January 11, 2024

Featuring articles on a drug-eluting scaffold for infrapopliteal disease, a phase 2 trial of sibeprenlimab in IgA nephropathy, liquefied petroleum gas cooking and the effects on severe infant pneumonia and on stunting in infants; a review article on communicating about serious illness and end of life; a Clinical Problem-Solving describing a swell diagnosis; and Perspective articles on the Journal’s historical “Indian Problem”.

NEJM This Week — January 4, 2024

Featuring articles on dual or single antiplatelet treatment up to 72 hours after stroke, nirsevimab for prevention of RSV hospitalization in infants, sparsentan in focal segmental glomerulosclerosis, transfusion strategy in patients with myocardial infarction and anemia, and the effect of alcohol reduction on cancer incidence; a review article on wearable technology in clinical practice for depressive disorder; a case report of a woman with cough and shortness of breath; and Perspective articles on community-based doulas, on a new era for research funded by the U.S. government, and on the poet as patient.

NEJM This Week — December 28, 2023

Featuring articles on percutaneous coronary intervention for stable angina, doxycycline prophylaxis to prevent STIs in women, simvastatin for critically ill patients with Covid-19, and melioidosis in Mississippi; a review article on eye infections; a case report of a woman with chronic diarrhea and skin changes; and Perspective articles on when patients lose decision-making capacity, on silencing the FDA’s voice, and on being hidden behind bars.

NEJM This Week — December 21, 2023

Featuring articles on semaglutide for prevention of cardiovascular events, an mRNA-based RSV PreF vaccine in older adults, recombinant or standard-dose influenza vaccine, tebentafusp in metastatic uveal melanoma, and on the predominance of Medicare Advantage; a review article on cannabis-related disorders and toxic effects; a case report of a woman with abnormal movements and confusion; and Perspective articles on medicine’s lessons for AI regulation, on “unwinding” continuous Medicaid coverage, and on something for sleep.

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